New antimicrobial developed to combat coronaviruses

Using the natural forces of air and light, scientists have unveiled a potential new “weapon” in the war against human coronaviruses.

Laboratory tests carried out on face masks treated with a chemical agent that produces a potent form of oxygen when activated by light, have shown that it can destroy human coronaviruses closely related to SARS-CoV-2, the coronavirus that causes COVID-19. 

Microbiologist Dr. David Webber, who has advised the NHS on hospital infection control and was involved with the legislation for the control of Legionnaire’s Disease, said it was “probably the most important breakthrough in infection control for almost half a century.”

The tests with SingloTex, conducted by scientists at the accredited Perfectus-Biomed laboratories at SciTech science park at Daresbury, Cheshire, showed that almost 99% of the human coronavirus 229E deposited on the masks were inactivated after exposure to light.

Dr Webber said: “This is a very exciting development with far-reaching potential for infection control by eradicating pathogenic bacteria and viruses on a vast range of both soft and hard surfaces.                                                                      

“The ability to deactivate human coronavirus on face masks, as proven by the test results, could be extended to all forms of PPE (personal protective equipment) in all clinical and medical settings - including surgical gowns, aprons, gloves and goggles.

“SingloTex is a photocatalytic agent that can be deposited on or integrated into almost any hard surface including plastics, metal, glass and composites and, as such, it has vast potential as an antimicrobial treatment for medical and surgical instruments and appliances, food processing equipment and sanitary ware.”

Wearing a face mask has been shown to reduce transmission of coronavirus by at least 50% but if the mask had been treated with SingloTex this would “produce a further significant level of protection” both for the wearer and others who came into contact with them.

“This is especially critical for all frontline hospital and healthcare workers but also for anyone in any setting who has to wear a face mask or face covering in public,” he said.

The patented technology, based on a class of well-documented and scientifically researched dyes called phthalocyanines, was invented and developed by chemist Barry Noar, a former research scientist at AstraZeneca in Cheshire.

Noar said: “By pure coincidence the first batches of SingloTex went into production at a UK company in Yorkshire around the same time as the world found itself in the grip of the COVID-19 pandemic.

“We have for some time been aware of the potential lifesaving potential of SingloTex, especially on items of PPE, and this has been brought sharply into focus by the pandemic and the global demand for protective equipment. We are greatly encouraged by the fact that laboratory tests showed that it can destroy human coronaviruses in the same family as SARS-CoV-2.

“Unlike conventional surface disinfectant processes using harmful chemicals such as sodium hypochlorite (bleach), ozone and quaternary ammonium components, SingloTex is totally safe and is amazingly potent and effective in destroying harmful viruses and bacteria. Essentially, SingloTex is a novel and highly versatile deposition technology that permits the dye to be deposited onto a range of materials that includes textiles, plastics, paints and almost all hard surfaces.

“The singlet oxygen it produces when triggered by either natural or artificial light, means that, in effect, we are deploying the air we breathe and the light around us to destroy viruses and bacteria. It is satisfying to think that it has such a wide range of uses in so many disparate sectors and, most importantly, can protect lives.”

To investigate its antimicrobial potential in a broad spectrum of medical and industrial sectors, a UK company, Singlotech, was set up in June 2019 and within recent months two licensing agreements have been drawn up with UK companies.

One is with OGM, a plastic moulding company in Kidlington, Oxfordshire, who are proposing to use SingloTex technology in food packaging and the inks used to print on them, and the other with Churchill PPS of Lichfield, Staffordshire, that has a special interest in the use of SingloTex in military fabrics.  

Noar added: “For the immediate future, we will clearly be preoccupied with the antiviral and antimicrobial applications for SingloTex and especially its potential in the control of coronaviruses, but in the longer term, I am especially keen to see it extended into the field of photodynamic therapy (PDT) in the fight against diseased tissue.

“I started my career as a chemist in the pharmaceutical industry developing drugs that would help save people’s lives and it would be very gratifying to come full circle and see SingloTex used routinely for patients being treated with PDT.”

SingloTex is being manufactured in the UK by Eye-Dale Limited of Bradford in Yorkshire, an independent chemical consultancy and contract research organisation.