New ways in which nanopillars can damage bacteria have been identified in a study by the University of Bristol.
Professor Bo Su, University of Bristol
The findings, published in Nature Communications, could aid the design of better antimicrobial surfaces for potential biomedical applications such as medical implants and devices that are not reliant on antibiotics.
Bo Su, professor of biomedical materials at the University of Bristol’s Dental School, who authored the research said: “In this work, we sought to better understand nanopillar-mediated bactericidal mechanisms. The current dogma is that nanopillars kill bacteria by puncturing bacterial cells, resulting in lysis. However, our study shows that the antibacterial effects of nanopillars are actually multifactorial, nanotopography- and species-dependent.
“Alongside deformation and subsequent penetration of the bacterial cell envelope by nanopillars, particularly for Gram-negative bacteria, we found the key to the antibacterial properties of these nanopillars might also be the cumulative effects of physical impedance and induction of oxidative stress.
“We can now hopefully translate this expanded understanding of nanopillar-bacteria interactions into the design of improved biomaterials for use in real world applications.”
Funded by the Medical Research Council, the implications of the research could be far-reaching.
Professor Su added: “Now we understand the mechanisms by which nanopillars damage bacteria, the next step is to apply this knowledge to the rational design and fabrication of nanopatterned surfaces with enhanced antimicrobial properties.
“Additionally, we will investigate the human stem cell response to these nanopillars, so as to develop truly cell-instructive implants that not only prevent bacterial infection but also facilitate tissue integration.”
